{"id":682,"date":"2017-04-16T02:54:38","date_gmt":"2017-04-16T02:54:38","guid":{"rendered":"https:\/\/pressbooks.hccfl.edu\/bio1\/chapter\/7-9-metabolism-of-molecules-other-than-glucose\/"},"modified":"2025-08-29T18:15:15","modified_gmt":"2025-08-29T18:15:15","slug":"7-9-metabolism-of-molecules-other-than-glucose","status":"publish","type":"chapter","link":"https:\/\/pressbooks.hccfl.edu\/bio1\/chapter\/7-9-metabolism-of-molecules-other-than-glucose\/","title":{"raw":"Metabolism of molecules other than glucose","rendered":"Metabolism of molecules other than glucose"},"content":{"raw":"You have learned about the catabolism of glucose, which provides energy to living cells. But living things consume more than just glucose for food. How does a turkey sandwich, which contains various carbohydrates, lipids, and protein, provide energy to your cells?\n\nBasically, all of these molecules from food are converted into molecules that can enter the cellular respiration pathway somewhere. Some molecules enter at glycolysis, while others enter at the citric acid cycle. This means that all\u00a0of the catabolic pathways for carbohydrates, proteins, and lipids eventually connect into glycolysis and the citric acid cycle pathways. Metabolic pathways should be thought of as porous\u2014that is, substances enter from other pathways, and other substances leave for other pathways. These pathways are not closed systems. Many of the products in a particular pathway are reactants in other pathways.\n<h1>Carbohydrates<\/h1>\nSo far, we have discussed the carbohydrate from which\u00a0organisms derive the majority of their energy: glucose. Many carbohydrate molecules can be broken down into glucose or otherwise processed into glucose by the body. <strong>Glycogen,<\/strong> a polymer of glucose, is a short-term energy storage molecule in animals (<strong>Figure 1<\/strong>). When there is plenty of\u00a0ATP present, the extra\u00a0glucose is converted into glycogen for storage. Glycogen is made and stored in the liver and muscle. Glycogen will be taken out of storage if blood sugar levels drop. The presence of glycogen in muscle cells as a source of glucose allows\u00a0ATP to be produced for a longer time during exercise.\n\n[caption id=\"attachment_680\" align=\"alignnone\" width=\"234\"]<img class=\"wp-image-407 size-medium\" src=\"http:\/\/pressbooks.hccfl.edu\/bio1\/wp-content\/uploads\/sites\/106\/2017\/04\/Glycogen-234x300-1.png\" alt=\"glycogen\" width=\"234\" height=\"300\"> <strong>Figure 1<\/strong> Glycogen is made of many molecules of glucose attached together into branching chains. Each of the balls in the bottom diagram represents one molecule of glucose. (Credit: <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Glycogen.png\">Glycogen<\/a> by <a href=\"https:\/\/en.wikipedia.org\/wiki\/User:BorisTM\">BorisTM<\/a>. This work has been released into the public domain)[\/caption]\n\nMost other carbohydrates enter the cellular respiration pathway during glycolysis. For example, <strong>sucrose<\/strong> is a disaccharide made from glucose and fructose bonded together. Sucrose is broken down in the small intestine. The glucose enters the beginning of glycolysis as previously discussed, while fructose can be slightly modified and enter glycolysis at the third step.\u00a0<strong>Lactose,<\/strong> the disaccharide sugar found in milk, can be broken down by lactase enzyme into two smaller sugars: galactose and glucose. Like fructose, galactose can be slightly modified to enter glycolysis.\n\nBecause these carbohydrates enter near the beginning of glycolysis, their\u00a0catabolism (breakdown) produces the same number of ATP molecules as glucose.\n<h1>Proteins<\/h1>\nProteins are broken down by a variety of enzymes in cells. Most of the time, amino acids are recycled into new proteins and not used as a source of energy. This is because it is more energy efficient to reuse amino acids rather than making new ones from scratch.\u00a0The body will use protein as a source of energy\u00a0if:\n<ul>\n \t<li>There are excess amino acids (you consume a lot of protein)<\/li>\n \t<li>The body is in a state of famine (you are starving and have no other source of energy available)<\/li>\n<\/ul>\nWhen proteins are used in the cellular respiration pathway, they are first broken down into individual amino acids. The amino group from each amino acid is removed (deaminated) and is converted into ammonia. In mammals, the liver synthesizes urea from two ammonia molecules and a carbon dioxide molecule. Thus, urea is the principal waste product in mammals from the nitrogen originating in amino acids, and it leaves the body in urine.\n\nOnce the amino acid has been deaminated, its chemical properties determine which intermediate of the cellular respiration pathway it will be converted into. These intermediates enter cellular respiration at various places in the Citric Acid Cycle (<strong>Figure 2<\/strong>).\n\n[caption id=\"attachment_680\" align=\"alignnone\" width=\"800\"]<img class=\"wp-image-680 size-full\" src=\"http:\/\/pressbooks.hccfl.edu\/bio1\/wp-content\/uploads\/sites\/106\/2025\/08\/Figure_07_06_01-protein-metabolism-TCA.jpg\" alt=\"protein metabolism in the TCA\" width=\"800\" height=\"524\"> <strong>Figure 2<\/strong> The carbon skeletons of certain amino acids (indicated in boxes) derived from proteins can feed into the citric acid cycle. (credit: modification of work by Mikael H\u00e4ggstr\u00f6m)[\/caption]\n<h1>Lipids<\/h1>\nTriglycerides (fats) are a form of long-term energy storage in animals. Triglycerides store about twice as much energy as carbohydrates. Triglycerides are made of glycerol and three fatty acids. Glycerol can enter\u00a0glycolysis. Fatty acids are broken into two-carbon units that enter the citric acid cycle (<strong>Figure 3<\/strong>).\n\n[caption id=\"attachment_680\" align=\"alignnone\" width=\"300\"]<img class=\"wp-image-118 size-medium\" src=\"http:\/\/pressbooks.hccfl.edu\/bio1\/wp-content\/uploads\/sites\/106\/2025\/08\/Figure_04_20-300x131-1.jpg\" alt=\"entry of other molecules diagram\" width=\"300\" height=\"131\"> <strong>Figure 3<\/strong>\u00a0Glycogen from the liver and muscles, together with fats, can feed into the catabolic pathways for carbohydrates.[\/caption]\n\nRemember that if oxygen is not available, glycolysis can occur but not the citric acid cycle or oxidative phosphorylation. Since fatty acids enter the pathway at the citric acid cycle, they can not be broken down in the absence of oxygen. This means that if cells are not performing aerobic cellular respiration, the body can not burn fat for energy. This is why posters about the \"Fat Burning Zone\" in a gym specify that you need to have a lower heart rate \/ breathing rate to burn more fat - cells that are not doing aerobic respiration can't burn fat for fuel!\n\n[h5p id=\"153\"]\n<h1>References<\/h1>\nUnless otherwise noted, images on this page are licensed under <a href=\"https:\/\/mobile.mhcc.edu\/owa\/redir.aspx?C=fELq4h6Pt0ZToj0GTMFwdPEQ6w28kY5ckgbKyG9QmZ496IJSvdzTCA..&amp;URL=https%3a%2f%2fcreativecommons.org%2flicenses%2fby%2f4.0%2f\" target=\"_blank\" rel=\"noopener noreferrer\">CC-BY 4.0<\/a>\u00a0by\u00a0<a href=\"https:\/\/mobile.mhcc.edu\/owa\/redir.aspx?C=A5cEwLWl1r7AYbXIMefCCq5lXEDIZngk0oVPYclrOlQ96IJSvdzTCA..&amp;URL=https%3a%2f%2fopenstax.org%2f\" target=\"_blank\" rel=\"noopener noreferrer\">OpenStax<\/a>.\n\n<span class=\"name\">Text adapted from: OpenStax<\/span>, Concepts of Biology. OpenStax CNX. May 18, 2016 http:\/\/cnx.org\/contents\/b3c1e1d2-839c-42b0-a314-e119a8aafbdd@9.10","rendered":"<p>You have learned about the catabolism of glucose, which provides energy to living cells. But living things consume more than just glucose for food. How does a turkey sandwich, which contains various carbohydrates, lipids, and protein, provide energy to your cells?<\/p>\n<p>Basically, all of these molecules from food are converted into molecules that can enter the cellular respiration pathway somewhere. Some molecules enter at glycolysis, while others enter at the citric acid cycle. This means that all\u00a0of the catabolic pathways for carbohydrates, proteins, and lipids eventually connect into glycolysis and the citric acid cycle pathways. Metabolic pathways should be thought of as porous\u2014that is, substances enter from other pathways, and other substances leave for other pathways. These pathways are not closed systems. Many of the products in a particular pathway are reactants in other pathways.<\/p>\n<h1>Carbohydrates<\/h1>\n<p>So far, we have discussed the carbohydrate from which\u00a0organisms derive the majority of their energy: glucose. Many carbohydrate molecules can be broken down into glucose or otherwise processed into glucose by the body. <strong>Glycogen,<\/strong> a polymer of glucose, is a short-term energy storage molecule in animals (<strong>Figure 1<\/strong>). When there is plenty of\u00a0ATP present, the extra\u00a0glucose is converted into glycogen for storage. Glycogen is made and stored in the liver and muscle. Glycogen will be taken out of storage if blood sugar levels drop. The presence of glycogen in muscle cells as a source of glucose allows\u00a0ATP to be produced for a longer time during exercise.<\/p>\n<figure id=\"attachment_680\" aria-describedby=\"caption-attachment-680\" style=\"width: 234px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-407 size-medium\" src=\"http:\/\/pressbooks.hccfl.edu\/bio1\/wp-content\/uploads\/sites\/106\/2017\/04\/Glycogen-234x300-1.png\" alt=\"glycogen\" width=\"234\" height=\"300\" \/><figcaption id=\"caption-attachment-680\" class=\"wp-caption-text\"><strong>Figure 1<\/strong> Glycogen is made of many molecules of glucose attached together into branching chains. Each of the balls in the bottom diagram represents one molecule of glucose. (Credit: <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Glycogen.png\">Glycogen<\/a> by <a href=\"https:\/\/en.wikipedia.org\/wiki\/User:BorisTM\">BorisTM<\/a>. This work has been released into the public domain)<\/figcaption><\/figure>\n<p>Most other carbohydrates enter the cellular respiration pathway during glycolysis. For example, <strong>sucrose<\/strong> is a disaccharide made from glucose and fructose bonded together. Sucrose is broken down in the small intestine. The glucose enters the beginning of glycolysis as previously discussed, while fructose can be slightly modified and enter glycolysis at the third step.\u00a0<strong>Lactose,<\/strong> the disaccharide sugar found in milk, can be broken down by lactase enzyme into two smaller sugars: galactose and glucose. Like fructose, galactose can be slightly modified to enter glycolysis.<\/p>\n<p>Because these carbohydrates enter near the beginning of glycolysis, their\u00a0catabolism (breakdown) produces the same number of ATP molecules as glucose.<\/p>\n<h1>Proteins<\/h1>\n<p>Proteins are broken down by a variety of enzymes in cells. Most of the time, amino acids are recycled into new proteins and not used as a source of energy. This is because it is more energy efficient to reuse amino acids rather than making new ones from scratch.\u00a0The body will use protein as a source of energy\u00a0if:<\/p>\n<ul>\n<li>There are excess amino acids (you consume a lot of protein)<\/li>\n<li>The body is in a state of famine (you are starving and have no other source of energy available)<\/li>\n<\/ul>\n<p>When proteins are used in the cellular respiration pathway, they are first broken down into individual amino acids. The amino group from each amino acid is removed (deaminated) and is converted into ammonia. In mammals, the liver synthesizes urea from two ammonia molecules and a carbon dioxide molecule. Thus, urea is the principal waste product in mammals from the nitrogen originating in amino acids, and it leaves the body in urine.<\/p>\n<p>Once the amino acid has been deaminated, its chemical properties determine which intermediate of the cellular respiration pathway it will be converted into. These intermediates enter cellular respiration at various places in the Citric Acid Cycle (<strong>Figure 2<\/strong>).<\/p>\n<figure id=\"attachment_680\" aria-describedby=\"caption-attachment-680\" style=\"width: 800px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-680 size-full\" src=\"http:\/\/pressbooks.hccfl.edu\/bio1\/wp-content\/uploads\/sites\/106\/2025\/08\/Figure_07_06_01-protein-metabolism-TCA.jpg\" alt=\"protein metabolism in the TCA\" width=\"800\" height=\"524\" srcset=\"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-content\/uploads\/sites\/106\/2025\/08\/Figure_07_06_01-protein-metabolism-TCA.jpg 800w, https:\/\/pressbooks.hccfl.edu\/bio1\/wp-content\/uploads\/sites\/106\/2025\/08\/Figure_07_06_01-protein-metabolism-TCA-300x197.jpg 300w, https:\/\/pressbooks.hccfl.edu\/bio1\/wp-content\/uploads\/sites\/106\/2025\/08\/Figure_07_06_01-protein-metabolism-TCA-768x503.jpg 768w, https:\/\/pressbooks.hccfl.edu\/bio1\/wp-content\/uploads\/sites\/106\/2025\/08\/Figure_07_06_01-protein-metabolism-TCA-65x43.jpg 65w, https:\/\/pressbooks.hccfl.edu\/bio1\/wp-content\/uploads\/sites\/106\/2025\/08\/Figure_07_06_01-protein-metabolism-TCA-225x147.jpg 225w, https:\/\/pressbooks.hccfl.edu\/bio1\/wp-content\/uploads\/sites\/106\/2025\/08\/Figure_07_06_01-protein-metabolism-TCA-350x229.jpg 350w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-680\" class=\"wp-caption-text\"><strong>Figure 2<\/strong> The carbon skeletons of certain amino acids (indicated in boxes) derived from proteins can feed into the citric acid cycle. (credit: modification of work by Mikael H\u00e4ggstr\u00f6m)<\/figcaption><\/figure>\n<h1>Lipids<\/h1>\n<p>Triglycerides (fats) are a form of long-term energy storage in animals. Triglycerides store about twice as much energy as carbohydrates. Triglycerides are made of glycerol and three fatty acids. Glycerol can enter\u00a0glycolysis. Fatty acids are broken into two-carbon units that enter the citric acid cycle (<strong>Figure 3<\/strong>).<\/p>\n<figure id=\"attachment_680\" aria-describedby=\"caption-attachment-680\" style=\"width: 300px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-118 size-medium\" src=\"http:\/\/pressbooks.hccfl.edu\/bio1\/wp-content\/uploads\/sites\/106\/2025\/08\/Figure_04_20-300x131-1.jpg\" alt=\"entry of other molecules diagram\" width=\"300\" height=\"131\" \/><figcaption id=\"caption-attachment-680\" class=\"wp-caption-text\"><strong>Figure 3<\/strong>\u00a0Glycogen from the liver and muscles, together with fats, can feed into the catabolic pathways for carbohydrates.<\/figcaption><\/figure>\n<p>Remember that if oxygen is not available, glycolysis can occur but not the citric acid cycle or oxidative phosphorylation. Since fatty acids enter the pathway at the citric acid cycle, they can not be broken down in the absence of oxygen. This means that if cells are not performing aerobic cellular respiration, the body can not burn fat for energy. This is why posters about the &#8220;Fat Burning Zone&#8221; in a gym specify that you need to have a lower heart rate \/ breathing rate to burn more fat &#8211; cells that are not doing aerobic respiration can&#8217;t burn fat for fuel!<\/p>\n<div id=\"h5p-153\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-153\" class=\"h5p-iframe\" data-content-id=\"153\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"metabolism of molecules other than glucose\"><\/iframe><\/div>\n<\/div>\n<h1>References<\/h1>\n<p>Unless otherwise noted, images on this page are licensed under <a href=\"https:\/\/mobile.mhcc.edu\/owa\/redir.aspx?C=fELq4h6Pt0ZToj0GTMFwdPEQ6w28kY5ckgbKyG9QmZ496IJSvdzTCA..&amp;URL=https%3a%2f%2fcreativecommons.org%2flicenses%2fby%2f4.0%2f\" target=\"_blank\" rel=\"noopener noreferrer\">CC-BY 4.0<\/a>\u00a0by\u00a0<a href=\"https:\/\/mobile.mhcc.edu\/owa\/redir.aspx?C=A5cEwLWl1r7AYbXIMefCCq5lXEDIZngk0oVPYclrOlQ96IJSvdzTCA..&amp;URL=https%3a%2f%2fopenstax.org%2f\" target=\"_blank\" rel=\"noopener noreferrer\">OpenStax<\/a>.<\/p>\n<p><span class=\"name\">Text adapted from: OpenStax<\/span>, Concepts of Biology. OpenStax CNX. May 18, 2016 http:\/\/cnx.org\/contents\/b3c1e1d2-839c-42b0-a314-e119a8aafbdd@9.10<\/p>\n","protected":false},"author":130,"menu_order":9,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":["lisa-bartee-8iamvryfkq","shriner-waiter-s570sonk1t","catherine-creech-qsectufgaw"],"pb_section_license":"cc-by"},"chapter-type":[],"contributor":[85,83,84],"license":[53],"class_list":["post-682","chapter","type-chapter","status-publish","hentry","contributor-catherine-creech-qsectufgaw","contributor-lisa-bartee-8iamvryfkq","contributor-shriner-waiter-s570sonk1t","license-cc-by"],"part":644,"_links":{"self":[{"href":"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-json\/pressbooks\/v2\/chapters\/682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-json\/wp\/v2\/users\/130"}],"version-history":[{"count":2,"href":"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-json\/pressbooks\/v2\/chapters\/682\/revisions"}],"predecessor-version":[{"id":725,"href":"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-json\/pressbooks\/v2\/chapters\/682\/revisions\/725"}],"part":[{"href":"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-json\/pressbooks\/v2\/parts\/644"}],"metadata":[{"href":"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-json\/pressbooks\/v2\/chapters\/682\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-json\/wp\/v2\/media?parent=682"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-json\/pressbooks\/v2\/chapter-type?post=682"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-json\/wp\/v2\/contributor?post=682"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.hccfl.edu\/bio1\/wp-json\/wp\/v2\/license?post=682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}